http://repository.uhamka.ac.id/885/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/885/1/B18.pdf Download Disini !

http://repository.uhamka.ac.id/886/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/886/1/B19.pdf Download Disini !

Paederia foetida, locally (Indonesia) known as “sembukan “and “skunkvine” (English), is one of Rubiaceae family member that has a diverse pharmacological and phytochemical importance. The name derives from the distinct odor when the leaves are crushed. The species name “foetida” is a Latin word for “stinky” or “foul smelling”. The current work was investigated to perform the morphoanatomical, physicochemical, phytochemical analysis and flavonoids content of Paederia foetida Linn. Pharmacognostical studies were carried out for different parameters include macroscopic, microscopic, and fluorescence. Physicochemical parameters, like the loss on drying, ash value, extractive values, etc. were measured as per WHO guidelines. Preliminary phytochemical screening was also performed for major groups of compounds and the flavonoid content. The TLC profile of the leaves extracts (n-hexane, DCM and ethanolic) of P. foetida showed 9, 7 and 3 spots respectively in the different solvents. The total flavonoid concentration was 1.32 mg/g, expressed as quercetin equivalents. The various macroscopic, microscopic, physical and phytochemical parameters listed here for P. foetida, and the present work can be used with respect to its identification, authentication, and standardization.

http://repository.uhamka.ac.id/887/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/887/1/B20.pdf Download Disini !

Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients with various complications that cause polypharmacy which can increase the risk of drug-drug interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse events in geriatric patients with CKD. This was a descriptive study where the samples were collected retrospectively from medical record of the patients admitted in one tertiary care hospital in Jakarta. Potential drug interaction was screened electronically using a drug interaction checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60% with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion, The prevalence of DDIs in geriatric patients with CKD was found high and major level of significance adverse event hyperkalemia was found caused by the DDIs.

http://repository.uhamka.ac.id/888/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/888/1/B21.pdf Download Disini !

Indonesian people use bay leaves as spices in local culinary and as traditional medicine, particularly to treat diabetes. The problems with the mass production of antidiabetic drugs from bay leaves can be solved by utilizing endophytic fungi as an alternative source for antidiabetic compounds. This study aimed to isolate endophytic fungi from bay leaves and identify their antidiabetic activity through the in vitro inhibition of alpha-amylase. The leaves were processed on potato dextrose agar media, and five isolates were grown in an agar medium. The fermentation used a potato dextrose yeast medium that was left for five days on an orbital shaker at room temperature. The crude was extracted using ethyl acetate solvent. In the in vitro alpha-amylase inhibition test, the antidiabetic assay used the ethyl acetate extract of the endophytic fungi. The inhibition percentage was calculated from the absorbance value read by a microplate reader. All isolates inhibited alpha-amylase activity, but only three of them had high inhibition percentages (14.385%, 12.849%, and 39.246%). As a conclusion, the endophytic fungi isolated from bay leaves are potential as an alternative source for the production of secondary metabolites to cure diabetes.

http://repository.uhamka.ac.id/889/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/889/1/B22.pdf Download Disini !

Background: The present study aimed to formulate and evaluate the stability, characteristics and effectiveness of glutathione-loaded alginate microspheres through increased lipophilicity using surfactant with a Hydrophylic-Lipophilic Balance (HLB) value equal to 7. The selection of glutathione as an antioxidant was based on its prominent role in maintaining intracellular redox balance. Alginate was used as the polymer, while calcium chloride constituted a cross-linking agent and Tween and Span were employed as surfactants. Methods: The study applied an ionotropic gelation-aerosolization method. Microspheres were characterized by their morphology, size, drug loading, entrapment efficiency and yield. Stress testing utilized a forced degradation method, while an effectiveness study of glutathione incorporated a Matrix Metalloproteinase I (MMP-1) parameter on mouse skin. Glutathione-microspheres, to which had been added surfactants with a HLB value equal to 7, were compared to those without surfactants. Results: Microspheres demonstrated both high yield and encapsulation efficiency. From the stability study conducted, it was evident that the glutathione-microspheres with additional surfactant were more stable than glutathione with surfactant, but without microspheres. Similarly, the glutathione-microspheres with additional surfactant were more stable than the glutathione without surfactant. The in vivo effectivity showed lipophilic glutathione microspheres were able to decrease MMP-1 expression in the dermis tissue of mice. Conclusion: The results of freeze-dried glutathione-loaded alginate microspheres with surfactant with a HLB value equal to 7 can be utilized as potential glutathione delivery systems.

http://repository.uhamka.ac.id/890/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/890/1/B23.pdf Download Disini !